Dr. Rosenblatt’s leading-edge research focuses on developing new therapies that target cancer cells with higher accuracy, moving from a shotgun approach to focused therapies for patients with aggressive cancers. The Rosenblatt laboratory has developed personalized cancer treatments based on molecular and immunological analyses of tumors. The result: more effective therapies with fewer side effects.

The team is also drilling down to the genetic level of tumors to understand the driving forces behind specific cancers. In studying gene expression of tumors, they have been able to identify surprising drug treatments. For example, a drug that was developed for one mutated gene in melanoma turned out to be extremely useful in hairy cell leukemia. The molecular evidence links two diseases that would normally be considered unrelated, broadening the field for collaboration and more rapid advances in the science.

Dr. Rosenblatt and his team are also currently identifying new therapeutic agents, such as antibody fusion proteins that inhibit the growth of cancer cells, which could revolutionize the fight against cancer. They are implementing treatments that block cancer from metastasizing, which can reduce cancer cells  to a non-detectable level in the blood. This could be a lifelong reprieve for some types of cancer. The team is now in the clinical testing phase with one of the proteins created in the Rosenblatt lab.